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Thursday, May 21, 2020 | History

2 edition of design of non-viral peptide-based delivery vehicles. found in the catalog.

design of non-viral peptide-based delivery vehicles.

Kim S. Kawamura

design of non-viral peptide-based delivery vehicles.

by Kim S. Kawamura

  • 335 Want to read
  • 26 Currently reading

Published .
Written in English


The Physical Object
Pagination171 leaves.
Number of Pages171
ID Numbers
Open LibraryOL19014818M
ISBN 100612691799

  Nanocarriers for drug delivery. Nanomedicine is a rapidly developing area that is revolutionizing cancer diagnosis and therapy. Nanoparticles Cited by: When one of the selected peptides was conjugated to an antisense oligonucleotide against the ErbB2 receptor, specific delivery to breastcancer cells was demonstrated. The established biopanning procedure should help in the rational selection of cancer-targeting peptides for specific delivery of DNA and RNA oligonucleotides into cancer by:

Title: Dendritic Peptide-Based Carriers for Gene Delivery VOLUME: 6 ISSUE: 4 Author(s):Daniel J. Coles and Istvan Toth Affiliation:School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia. Keywords:Gene delivery, non-viral carriers, dendrimers, cell penetrating peptides Abstract: Gene delivery research has come a long way in recent years but Cited by: 7.   A number of human diseases stem from defective genes. One approach to treating such diseases is to replace, or override, the defective genes with normal genes, an .

Non-viral gene therapy uses engineered nanoparticles in the virus size range for the cell-targeted delivery of therapeutic nucleic acids. A diverse range of macromolecules are suitable for constructing such ‘artificial viruses’. However, proteins, either man-made or from natural sources, are especially convenient for mimicking the viral functions critical for gene by: It covers the history and current and future applications of gene transfer in cancer, and provides expert insight on the progress of viral and non-viral gene therapy with regard to delivery system, vector design, potential therapeutic genes, and principles and regulations for cancer gene : Hardcover.


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Design of non-viral peptide-based delivery vehicles by Kim S. Kawamura Download PDF EPUB FB2

Loligomers and vaccine design. The development of non-viral, peptide-based constructs able to elicit protective in vivo cytotoxic T-lymphocyte (CTL) responses represents a major challenge in designing effective future by:   Over the past two decades, gene therapy has garnered tremendous attention and is heralded by many as the ultimate cure to treat diseases such as cancer, viral infections, and inherited genetic disorders.

However, the therapeutic applications of nucleic acids extend beyond the delivery of double-stranded DNA and subsequent expression of deficient gene products in diseased tissue. Other Cited by: A microtubule targeted peptide-based delivery vehicle has been designed using two oppositely charged peptides, which targets tubulin/microtubules, delivers both hydrophilic and hydrophobic drugs into their target site through lysosome at acidic pH.

Drug loaded vesicles show a significant anticancer effect co. Meanwhile, four types of RGD peptide based non-viral gene delivery vectors for cancer therapy, including RGD based cationic polymers, lipids, peptides and hybrid systems, are summarized. The MAP system: a flexible and unambiguous vaccine design of branched peptides.

Design of experimental synthetic peptide immunogens for prevention of HIV-1 and HTLV-I retroviral infections. Design and testing of peptide-based cytotoxic T-cell-mediated immunotherapeutics to treat infectious diseases and cancer.

Charge-Reversal Lipids, Peptide-Based Lipids, and Nucleoside-Based Lipids for Gene Delivery. Accounts of Chemical Research45 (7), DOI: /ary.

Asier Unciti-Broceta, Juan José Díaz-Mochón, Rosario M. Sánchez-Martín, and Mark by:   The major advantage of using non-viral vectors is its bio-safety. However the application of non-viral gene transfer have been ignored for a long time in past because of their poor efficiency of delivery thereby low transient expression of their transgenes.

Non-viral vectors have drawn significant attention due to its less by: Chapter Six - Implications of Protein- and Peptide-Based Nanoparticles as Potential Vehicles for Anticancer Drugs Ahmed O. Elzoghby, Mayada M. Elgohary, Nayra M. Kamel Pages Viral gene delivery has been extensively studied and developed for research and clinical applications due to its high efficiency in delivering genetic cargo [5], but viral vectors have design and.

Peptide-based systems are considered one of the tools that may be used in drug and gene delivery. Peptides are small molecules, are easy to obtain, may be chemically modified, are stable in a broad range of biological conditions, are able to cross the plasma membranes of cells and deliver the cargo into the cytosol or the nucleus, and usually Author: Dana M.

Copolovici, Andreea I. Lupitu. This book will be a valuable resource not only as a reference book for the researcher engaged in academic and pharmaceutical setting, from basic research to manufacturing and from organic chemistry to biotechnology, but also a valuable resource to graduate students to understand discovery and development process for peptide-based : Hardcover.

Peptide-based delivery of nucleic acids: Design, mechanism of uptake and applications to splice-correcting oligonucleotides New arginine-rich CPPs allowing efficient splicing correction by conjugated PNAs (peptide nucleic acids) or PMO (phosphorodiamidate morpholino oligomer) steric blockers in the absence of endosomolytic agents have Cited by:   the proteasome as a key route for metabolism of peptide based non- viral gene delivery systems and provide a rationale for the use of proteasome inhibition to increase gene transfer efficiency.

The improvement of non-viral-based gene delivery systems is of prime importance for the future of gene and antisense therapies. We have previously described a peptide-based gene delivery system, MPG, derived from the fusion peptide domain of HIV-1 gp41 protein and the nuclear localisation sequence (NLS) of SV40 large T by: Title: Peptide-Based Matrices as Drug Delivery Vehicles VOLUME: 16 ISSUE: 9 Author(s):Kariem Ezzat, Samir EL Andaloussi, Rania Abdo and Ulo Langel Affiliation:Department of Neurochemistry,the Arrhenius Laboratories for Natural Sciences, Stockholm University, Svante Arrhenius v 21A, SE Stockholm, Sweden.

Keywords:Cell penetrating peptide, protein transduction domain, delivery, siRNA. Synthetic peptide-based gene delivery systems can be designed for DNA compaction, serum stability, cell-specific targeting, endosomo-lysis, cytoplasmic stability and nuclear transport.

The stability of compacted DNA under physiological conditions can be enhanced by the use of hydrophilic polymers, such as polyethylene by: The use of nanocarriers is being researched to achieve oral peptide delivery. Insulin-associated anionic polyelectrolyte nanoparticle complexes (PECs) were formed that comprised hyaluronic acid and chitosan in an optimum mass mixing ratio of (MR 5), followed by coating with a pH-dependent polymer.

In last few decades, non-viral delivery systems have gained attention because of their low toxicity, potential for targeted delivery, long-term stability, lack of immunogenicity, and relatively low production cost.

InFelgner et al. used the cationic lipid based non-viral gene delivery Cited by:   The improvement of non‐viral‐based gene delivery systems is of prime importance for the future of gene and antisense therapies.

We have previously described a peptide‐based gene delivery system, MPG, derived from the fusion peptide domain of HIV‐1 gp41 protein and the nuclear localisation sequence (NLS) of SV40 large T by: Kenneth Lundstrom, in Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies, Non-viral vectors.

Gene delivery based on non-viral vectors has attracted much attention due to their universal application range and high safety level of delivery. 5 A number of nanoparticle delivery systems based on polymers and liposomes have been developed.

Purchase Protein and Peptide Nanoparticles for Drug Delivery, Volume 98 - 1st Edition. Print Book & E-Book. ISBNIn recent years, research has shown the importance of peptides in neuroscience, immunology, and cell biology.

Active research programs worldwide are now engaged in developing peptide-based drugs and vaccines using modification of natural peptides and proteins, design of artificial peptides and peptide mimetics, and screening of peptide and phage libraries.5/5(1).A dual behavior is observed: on the one hand they can fulfill a structural and bioactive role.

In this review, we focus on the design and the characterization of drug delivery systems using peptide-based carriers; moreover, we will also highlight the peptide ability to self-assemble and to actively address nanosystems toward specific by: